Call backLog in
Search
Why choose us?
- Papers delivered punctually
- Written work that is entirely original and will pass any plagiarism test
- The highest quality papers with a 100% guarantee of satisfaction
- Ordering methods that are secure
- Customer support 24x7
- Affordably cheap prices
The enzyme delta-aminolevulinate Dehydratase (ALAD) is a part of the heme synthesis that converts its substrate, Aminolevulinic Acid into porphobilinogen. Porphobilinogen moves on through various reactions to finally synthesize heme that is crucial in forming various physiological functions. Key among these functions is the transport of oxygen that enables the body to optimally metabolize its nutrients via aerobic metabolism. The regulation of the oxidation states of compounds and radicals that are harmful to the body are also controlled by the heme cycle indirectly (Kelada, et al, 2001).
Lead toxicity that influences the ALAD not only depends on the extent of exposure, but also on certain genetic factors. Lead inhibits the action of ALAD in the heme cycle resulting in a low red cell count due to decrease of hemoglobin production. There are two variants of the gene that codes for ALAD that vary in affinity of lead; ALAD1 and ALAD2. These two variants of the enzyme differ in their affinity for lead. ALAD2 binds lead more than ALAD2. The ramification of this is that persons with ALAD2 will have the lead in their system bound, and thus stalling its physiological effects as its content in blood in is low. The symptoms of lead poisoning in this case also vary compared to those of persons with ALAD1 that will have high levels of lead in blood in case of poisoning (Kelada, et al, 2001).
Buy Free Custom «Role of ALAD in Lead Toxicology» Essay Paper paper online
In case of lead poisoning, the inhibition of the enzyme leads to an interruption of the heme cycle leading to the accumulation of substrate of delta-aminolevulinic acid(ALA) in urine and blood. This accumulation of ALA in the liver increases the propensity of getting liver cancer due to the acute intermittent porphyria that results from ALAD deficiency. Furthermore, heme production in the body declines with lead poisoning. The production of harmful reactive oxygen species (ROS) also occurs with the inhibition of ALAD.
FREE Extras:
- FREE revision (within 2 days)
- FREE title page
- FREE bibliography
- FREE outline (on request)
- FREE e-mail delivery
- FREE formatting
We Guarantee:
- Quality research and writing
- 24/7/365 Live support
- MA, BA, and PhD degree writers
- 100% Confidentiality
- No hidden charges
- Never resold works
- Complete authenticity
Paper Format:
- 12 pt. Times New Roman
- Double-spaced/Single-spaced papers
- 1 inch margins
- Any citation style
- Up-to-date sources only
- Fully referenced papers
Related Research essays
0
Preparing Orders
0
Active Writers
0%
Positive Feedback
0
Support Agents
